Gibbs J, Fauser D J, Rowe E A, Rolls B J, Rolls E T, Maddison S P
Nature. 1979 Nov 8;282(5735):208-10. doi: 10.1038/282208a0.
Bombesin (BBS) is a tetradecapeptide originally isolated from amphibian skin1. BBS-like immunoactivity is widely distributed in mammalian gut2-5, and plasma levels have been shown to rise sharply following feeding (ref. 6 and V. Erspamer, personal communication). The physiological actions of BBS are unknown. We have previously shown that the classic gut hormone cholecystokinin (CCK) is a powerful and specific suppressor of food intake7-9. Although CCK and BBS lack common amino acid sequences, they have certain common actions on gut viscera10,11. We have now shown that BBS also suppresses food intake, and we compare its action with that of CCK.
蛙皮素（BBS）是一种最初从两栖动物皮肤中分离出来的十四肽。蛙皮素样免疫活性广泛分布于哺乳动物肠道，并且已显示进食后血浆水平会急剧上升（参考文献6以及V. 埃斯帕默的个人交流）。蛙皮素的生理作用尚不清楚。我们之前已经表明，经典的肠道激素胆囊收缩素（CCK）是食物摄入的一种强大而特异的抑制剂。尽管CCK和BBS缺乏共同的氨基酸序列，但它们对肠道内脏有某些共同作用。我们现在已经表明，BBS也能抑制食物摄入，并且我们将其作用与CCK的作用进行了比较。
