Suzuki J, Yoshimoto T, Tanaka S, Mizoi K, Kagawa S
Hokkaido Igaku Zasshi. 1981 Jul;56(4):367-73.
Various therapeutic methods have been attempted for cerebral infarction, but the development of more effective methods is still awaited. We have investigations of the effect of mannitol in preventing the development of cerebral infarction and have reported it effects in clinical cases of operated cerebral aneurysms. In recent years, our attention has been drawn to the so-called red cell substitute, perfluorochemicals (FC), which has a high oxygen-carrying capacity and a small particle less than 0.1 mu. In the present studies, using infarction models in dogs which have previously developed and reported, observations are made on the recovery of brain electrical activity in sever ischemia, suppressing brain swelling following recirculation of cerebral blood flow and protection upon the hemorrhagic brain infarction, due to administration of mannitol or FC. These experimental results indicate that the combined administration of mannitol and FC is effective in protecting the brain from cerebral ischemia.
针对脑梗死，人们尝试了各种治疗方法，但仍期待能开发出更有效的方法。我们曾研究甘露醇在预防脑梗死发展方面的作用，并报告了其在脑动脉瘤手术临床病例中的效果。近年来，我们的注意力被所谓的红细胞替代物全氟化合物（FC）所吸引，它具有高携氧能力且颗粒小于0.1微米。在本研究中，利用先前建立并报道过的犬梗死模型，观察了因给予甘露醇或FC后，严重缺血时脑电活动的恢复情况、脑血流再灌注后脑肿胀的抑制情况以及对出血性脑梗死的保护作用。这些实验结果表明，甘露醇和FC联合给药对保护脑免受脑缺血损伤有效。
