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流感病毒RNA基因组片段的5'和3'末端核苷酸序列。

5' and 3' terminal nucleotide sequences of the RNA genome segments of influenza virus.

作者信息

Robertson J S

出版信息

Nucleic Acids Res. 1979 Aug 24;6(12):3745-57. doi: 10.1093/nar/6.12.3745.

DOI:10.1093/nar/6.12.3745
PMID:493121
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC327975/
Abstract

EXtensive nucleotide sequence analysis of the 5' and the 3' terminal of the RNA segments of the genome of fowl plague virus, an avian strain of influenza virus, confirms the presence of a common sequence at the 5' terminus of each segment and a common sequence at the 3' terminus of each segment. Between the ends of each individual segment there is a complementary sequence which may be important in the control of transcription and replication of the genome. In addition, the probable sites of initiation of translation of fowl plague virus mRNA are indicated along with the corresponding NH2-terminal amino acid sequences of the virus polypeptides.

摘要

对禽流感病毒鸡瘟病毒株基因组RNA片段的5'端和3'端进行的广泛核苷酸序列分析证实，每个片段的5'端存在一个共同序列，每个片段的3'端也存在一个共同序列。在每个单独片段的两端之间存在一个互补序列，这可能在基因组转录和复制的控制中起重要作用。此外，还指出了鸡瘟病毒mRNA可能的翻译起始位点以及病毒多肽相应的NH2端氨基酸序列。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e9c8/327975/6f95acfebbe1/nar00453-0041-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e9c8/327975/415c53488e73/nar00453-0038-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e9c8/327975/dbcf25b64892/nar00453-0040-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e9c8/327975/6f95acfebbe1/nar00453-0041-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e9c8/327975/415c53488e73/nar00453-0038-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e9c8/327975/dbcf25b64892/nar00453-0040-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e9c8/327975/6f95acfebbe1/nar00453-0041-a.jpg

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Polypeptides specified by the influenza virus genome I. Evidence for eight distinct gene products specified by fowl plague virus.流感病毒基因组所指定的多肽。I. 禽瘟病毒指定的八种不同基因产物的证据。
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