丝氨酸异羟肟酸对大肠杆菌生长的影响。
Effect of serine hydroxamate on the growth of Escherichia coli.
作者信息
Tosa T, Pizer L I
出版信息
J Bacteriol. 1971 Jun;106(3):966-71. doi: 10.1128/jb.106.3.966-971.1971.
Abstract
The structural analogue of l-serine, l-serine hydroxamate, inhibited the growth of Escherichia coli K-12. Of the other amino acid hydroxamates tested, only l-lysine hydroxamate reduced the rate of growth. Inhibition of growth by l-serine hydroxamate was rapidly reversed by the addition of l-serine to the bacterial culture or by removal of the analogue by filtration. The reversal of inhibition was specific for l-serine. l-Alanine, glycine, or adenine had no effect on an inhibited culture. No evidence for active transport of the analogue was obtained.
摘要
L-丝氨酸的结构类似物L-丝氨酸异羟肟酸抑制了大肠杆菌K-12的生长。在测试的其他氨基酸异羟肟酸中，只有L-赖氨酸异羟肟酸降低了生长速率。向细菌培养物中添加L-丝氨酸或通过过滤去除类似物，可迅速逆转L-丝氨酸异羟肟酸对生长的抑制作用。抑制作用的逆转对L-丝氨酸具有特异性。L-丙氨酸、甘氨酸或腺嘌呤对受抑制的培养物没有影响。未获得该类似物主动转运的证据。
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本文引用的文献
1
2
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Genetics. 1964 Oct;50(4):611-23. doi: 10.1093/genetics/50.4.611.
3
NUTRITIONAL AND REGULATORY ASPECTS OF SERINE METABOLISM IN ESCHERICHIA COLI.大肠杆菌中丝氨酸代谢的营养与调控方面
J Bacteriol. 1964 Sep;88(3):611-9. doi: 10.1128/jb.88.3.611-619.1964.
4
THE PATHWAY AND CONTROL OF SERINE BIOSYNTHESIS IN ESCHERICHIA COLI.大肠杆菌中丝氨酸生物合成的途径与调控
J Biol Chem. 1963 Dec;238:3934-44.
5
BIOSYNTHESIS OF SERINE IN ESCHERICHIA COLI AND SALMONELLA TYPHIMURIUM.大肠杆菌和鼠伤寒沙门氏菌中丝氨酸的生物合成
J Bacteriol. 1963 Jun;85(6):1431-9. doi: 10.1128/jb.85.6.1431-1439.1963.
6
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Bacteriol Rev. 1962 Sep;26(3):292-335. doi: 10.1128/br.26.3.292-335.1962.
7
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J Gen Physiol. 1961 Nov;45(2):355-69. doi: 10.1085/jgp.45.2.355.
8
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9
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