类风湿关节炎贫血患者中的促红细胞生成素

Erythropoietin in patients with anaemia in rheumatoid arthritis.

作者信息

Pavlović-Kentera V, Ruvidić R, Milenković P, Marinković D

出版信息

Scand J Haematol. 1979 Aug;23(2):141-5. doi: 10.1111/j.1600-0609.1979.tb02685.x.

DOI:10.1111/j.1600-0609.1979.tb02685.x

Abstract

Iron status and erythropoietin (Ep) level in serum and urine were determined in 30 patients with anaemia in rheumatoid arthritis. The anaemia in these patients was mild and fulfilled the criteria for anaemia of chronic disorders. The iron status of these patients differed from the iron status in patients with sideropenic anaemia. Serum Ep, level, measured indirectly by the polycythaemic mouse bioassay, was either not detected or when detected it did not correspond to the degree of anaemia. The data suggest that the failure to produce sufficient amount of Ep, among other causes, could be important in the pathogenesis of anaemia in rheumatoid arthritis.

摘要

对30例类风湿关节炎贫血患者的血清和尿液中的铁状态及促红细胞生成素（Ep）水平进行了测定。这些患者的贫血程度较轻，符合慢性病贫血的标准。这些患者的铁状态与缺铁性贫血患者的铁状态不同。通过红细胞增多症小鼠生物测定法间接测量的血清Ep水平，要么未检测到，要么检测到时与贫血程度不相符。数据表明，除其他原因外，未能产生足够量的Ep在类风湿关节炎贫血的发病机制中可能起重要作用。