类风湿关节炎患者血清免疫反应性促红细胞生成素：对贫血的反应受损。

Serum immunoreactive erythropoietin in rheumatoid arthritis: impaired response to anemia.

作者信息

Hochberg M C, Arnold C M, Hogans B B, Spivak J L

机构信息

Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205.

出版信息

Arthritis Rheum. 1988 Oct;31(10):1318-21. doi: 10.1002/art.1780311016.

DOI:10.1002/art.1780311016

PMID:3178910

Abstract

Serum immunoreactive erythropoietin (EP) levels were measured in 116 patients with rheumatoid arthritis (RA) and 20 control patients with iron deficiency anemia. Serum EP levels were significantly higher in the 46 anemic RA patients than in the 70 nonanemic RA patients (mean +/- SD 31.0 +/- 19.8 mU/ml versus 16.8 +/- 12.4 mU/ml; P less than 0.0001). Furthermore, although a significant inverse correlation between the serum EP level and the hemoglobin value was present in the anemic RA patients (r = -0.57, P less than 0.0001), the regression coefficient describing the relationship between serum EP and hemoglobin was significantly lower for the anemic RA patients than for patients with iron deficiency anemia (F = 6.01, P less than 0.025).

摘要

对116例类风湿关节炎（RA）患者和20例缺铁性贫血对照患者测定了血清免疫反应性促红细胞生成素（EP）水平。46例贫血RA患者的血清EP水平显著高于70例非贫血RA患者（均值±标准差为31.0±19.8 mU/ml对16.8±12.4 mU/ml；P<0.0001）。此外，虽然贫血RA患者血清EP水平与血红蛋白值之间存在显著负相关（r = -0.57，P<0.0001），但描述贫血RA患者血清EP与血红蛋白关系的回归系数显著低于缺铁性贫血患者（F = 6.01，P<0.025）。