Andersen J B, Dragsted L, Kann T, Johansen S H, Nielsen K B, Karbo E, Bentzen L
Scand J Respir Dis. 1979 Jun;60(3):151-6.
We studied the effects of resistive breathing in 10 patients with long-standing, severe disabling COPD. Small increases in inspiratory resistive load resulted in diaphragmatic fatigue and failure in all patients. Fatigue was detected using the frequency spectrum analysis of an EMG signal obtained with surface electrodes. Failure was defined as an inward displacement of the abdomen during inspiration, i.e. incoordination of thoracoabdominal motion. The patients trained for one half hour daily for 4 weeks, breathing into a simple device, where they inspired against a resistive load that produced some incoordinated breaths. After 4 weeks this load was increased, if possible, and another 4-week training period started. All patients improved with training, i.e. higher resistances could be tolerated without signs of fatigue and failure. In addition most patients claimed that training had helped them in their daily living; they were able to do more without getting short of breath. The device helped expectoration, possibly owing to the effect of the small expiratory resistance.
我们研究了10例患有长期严重致残性慢性阻塞性肺疾病（COPD）患者进行阻力呼吸的效果。吸气阻力负荷的小幅增加导致所有患者出现膈肌疲劳和衰竭。使用表面电极获取的肌电图信号频谱分析来检测疲劳。衰竭定义为吸气时腹部向内移位，即胸腹运动不协调。患者每天训练半小时，持续4周，通过一个简单的装置进行呼吸，在该装置中他们对抗产生一些不协调呼吸的阻力负荷进行吸气。4周后，如果可能，增加该负荷，并开始另一个为期4周的训练期。所有患者通过训练均有改善，即能够耐受更高的阻力而无疲劳和衰竭迹象。此外，大多数患者称训练对他们的日常生活有帮助；他们能够做更多事情而不会气短。该装置有助于咳痰，可能是由于小的呼气阻力的作用。
