通过放射性标记的单克隆抗体和外部闪烁扫描法检测肿瘤位置。
Tumor location detected with radioactively labeled monoclonal antibody and external scintigraphy.
作者信息
Ballou B, Levine G, Hakala T R, Solter D
出版信息
Science. 1979 Nov 16;206(4420):844-7. doi: 10.1126/science.493985.
PMID:493985
Abstract
Murine teratocarcinomas were located in mice by external gamma-ray scintigraphy with an iodine-125-labeled monoclonal antibody specific to the tumors. The specificity of the method was increased by subtracting the radiation produced by an iodine-125-labeled indifferent monoclonal antibody of the same immunoglobulin class as the tumor-specific antibody.
摘要
通过使用针对肿瘤的碘 - 125标记单克隆抗体进行外部γ射线闪烁扫描术来定位小鼠体内的畸胎癌。通过减去由与肿瘤特异性抗体相同免疫球蛋白类别的碘 - 125标记无关单克隆抗体产生的辐射，提高了该方法的特异性。
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