Freed W J, Perlow M J, Wyatt R J
Science. 1979 Nov 16;206(4420):850-2. doi: 10.1126/science.493987.
Subcutaneous and intracerebral injections of calcitonin inhibited feeding in rats. The anorectic activity of calcitonin was destroyed by exposing the hormone to heat, trypsin, or hydrogen peroxide. Calcitonin did not produce a conditioned taste aversion to saccharin, and maximum inhibition of feeding occurred 4.5 to 8.3 hours after subcutaneous administration. It is concluded that calcitonin inhibits feeding by acting directly on the central nervous system.
皮下和脑内注射降钙素可抑制大鼠进食。将该激素加热、用胰蛋白酶处理或用过氧化氢处理后，其抑制食欲的活性被破坏。降钙素不会引起对糖精的条件性味觉厌恶，皮下注射后4.5至8.3小时出现最大程度的进食抑制。结论是降钙素通过直接作用于中枢神经系统来抑制进食。
