蒽醌染料与质粒介导的OXA-2β-内酰胺酶的相互作用。
The interaction of anthraquinone dyes with the plasmid-mediated OXA-2 beta-lactamase.
作者信息
Monaghan C, Holland S, Dale J W
出版信息
Biochem J. 1982 Aug 1;205(2):413-7. doi: 10.1042/bj2050413.
Abstract
Although beta-lactamases do not require any nucleotide co-substrates, the OXA-2 type is inhibited competitively by Cibacron Blue 3GA, and by other anthraquinone dyes, including some simpler compounds with no side chain. The enzyme causes a red shift in the spectrum of Cibacron Blue. The beta-lactamase can be adsorbed in Blue Sepharose and specifically eluted by benzylpenicillin. These results indicate that the binding of anthraquinone dyes is a specific effect similar to that seen with many nucleotide-binding enzymes.
摘要
虽然β-内酰胺酶不需要任何核苷酸共底物，但OXA-2型β-内酰胺酶会受到汽巴克隆蓝3GA以及其他蒽醌染料（包括一些无侧链的更简单化合物）的竞争性抑制。该酶会使汽巴克隆蓝的光谱发生红移。β-内酰胺酶可被吸附于蓝色琼脂糖中，并可用苄青霉素特异性洗脱。这些结果表明，蒽醌染料的结合是一种特异性效应，类似于许多核苷酸结合酶所表现出的效应。
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