细菌性痢疾疫苗接种研究。4. 用活单型及联合疫苗进行口服免疫
Studies on vaccination against bacillary dysentery. 4. Oral immunization with live monotypic and combined vaccines.
作者信息
Mel D M, Arsić B L, Nikolić B D, Radovanić M L
出版信息
Bull World Health Organ. 1968;39(3):375-80.
Abstract
Results of tests made in 1964 confirm the previous findings that live oral vaccine, prepared from streptomycin-dependent strains of shigellae, confers a strong, type-specific protection against acute bacillary dysentery. This vaccine did not reduce the carrier rate of shigellae. Observations on soldiers treated with a vaccine of Shigella flexneri serotypes 2a and 3 combined revealed no antagonizing effects from the type 3 component upon the protective effect of the 2a component contained in the same vaccine.
摘要
1964年进行的测试结果证实了先前的研究发现，即由痢疾杆菌链霉素依赖株制备的口服活疫苗能对急性细菌性痢疾提供强大的、型特异性保护。这种疫苗并未降低痢疾杆菌的带菌率。对接受福氏志贺菌2a和3型联合疫苗治疗的士兵的观察表明，3型成分对同一疫苗中2a型成分的保护作用没有拮抗作用。
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本文引用的文献
1
Studies on vaccination against bacillary dysentery. 3. Effective oral immunization against Shigella flexneri 2a in a field trial.
Bull World Health Organ. 1965;32(5):647-55.
2
Studies on vaccination against bacillary dysentery. 2. Safety tests and reactogenicity studies on a live dysentery vaccine intended for use in field trials.
Bull World Health Organ. 1965;32(5):637-45.
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