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梅毒螺旋体（Nichols株）在兔睾丸中的细胞内定位。

Intracellular location of Treponema pallidum (Nichols strain) in the rabbit testis.

作者信息

Sykes J A, Miller J N

出版信息

Infect Immun. 1971 Sep;4(3):307-14. doi: 10.1128/iai.4.3.307-314.1971.

DOI:10.1128/iai.4.3.307-314.1971
PMID:4949494
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC416304/
Abstract

During investigations designed to obtain purified suspensions of virulent Treponema pallidum (Nichols strain), infected rabbit testicular tissue was routinely examined in the electron microscope. Morphologically typical T. pallidum were found intracellularly within the cytoplasmic substance of fibroblasts, interstitial and Leydig cells, and of spermatocytes. The importance of these observations to latency and treatment is discussed.

摘要

在旨在获取毒力梅毒螺旋体（Nichols株）纯化悬液的研究过程中，对感染的兔睾丸组织进行了常规电子显微镜检查。在成纤维细胞、间质细胞、睾丸间质细胞和精母细胞的细胞质内发现了形态典型的梅毒螺旋体。讨论了这些观察结果对潜伏期和治疗的重要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dfa0/416304/5fbb1cd335c1/iai00285-0137-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dfa0/416304/94ded862cf14/iai00285-0133-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dfa0/416304/c447647ad2fe/iai00285-0133-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dfa0/416304/c3c7f5eaff15/iai00285-0134-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dfa0/416304/62b6702bc688/iai00285-0134-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dfa0/416304/4c3009eeda9e/iai00285-0135-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dfa0/416304/5c7ec1479f77/iai00285-0135-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dfa0/416304/37d920371540/iai00285-0136-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dfa0/416304/666a2b88a58b/iai00285-0136-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dfa0/416304/5fbb1cd335c1/iai00285-0137-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dfa0/416304/94ded862cf14/iai00285-0133-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dfa0/416304/c447647ad2fe/iai00285-0133-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dfa0/416304/c3c7f5eaff15/iai00285-0134-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dfa0/416304/62b6702bc688/iai00285-0134-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dfa0/416304/4c3009eeda9e/iai00285-0135-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dfa0/416304/5c7ec1479f77/iai00285-0135-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dfa0/416304/37d920371540/iai00285-0136-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dfa0/416304/666a2b88a58b/iai00285-0136-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dfa0/416304/5fbb1cd335c1/iai00285-0137-a.jpg

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Treponema pallidum. A bibliographical review of the morphology, culture and survival of T. pallidum and associated organisms.梅毒螺旋体。梅毒螺旋体及相关生物体的形态、培养和存活的文献综述。
Bull World Health Organ. 1966;35(1):1-169.
2
An electron microscopic study of a syphilitic chancre. Engulfment of Treponema pallidum by plasma cells.梅毒初疮的电子显微镜研究。浆细胞对梅毒螺旋体的吞噬作用。
Arch Pathol. 1970 Aug;90(2):143-50.
3
Further studies of the morphology of Treponema pallidum under the electron microscope.梅毒螺旋体在电子显微镜下形态的进一步研究。
Syphilis vaccine: challenges, controversies and opportunities.
梅毒疫苗：挑战、争议与机遇。
Front Immunol. 2023 Apr 6;14:1126170. doi: 10.3389/fimmu.2023.1126170. eCollection 2023.
4
Classification and Staging of Morgellons Disease: Lessons from Syphilis.莫吉隆斯症的分类与分期：梅毒的教训
Clin Cosmet Investig Dermatol. 2020 Feb 7;13:145-164. doi: 10.2147/CCID.S239840. eCollection 2020.
5
Immune evasion and recognition of the syphilis spirochete in blood and skin of secondary syphilis patients: two immunologically distinct compartments.二期梅毒患者血液和皮肤中梅毒螺旋体的免疫逃逸与识别：两个免疫上截然不同的隔室。
PLoS Negl Trop Dis. 2012;6(7):e1717. doi: 10.1371/journal.pntd.0001717. Epub 2012 Jul 17.
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The immunopathobiology of syphilis: the manifestations and course of syphilis are determined by the level of delayed-type hypersensitivity.梅毒的免疫病理生物学：梅毒的表现和病程由迟发型超敏反应的水平决定。
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Antigenic variation in Treponema pallidum: TprK sequence diversity accumulates in response to immune pressure during experimental syphilis.梅毒螺旋体的抗原变异：在实验性梅毒过程中，TprK 序列的多样性因免疫压力而积累。
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