Joncas J, Chagnon A, Pavilanis V
Can Med Assoc J. 1966 May 7;94(19):986-95.
Viral studies were carried out on throat swabs, rectal swabs and washed white blood cells from 27 cases of infectious mononucleosis (positive Paul-Bunnell-David-sohn test), and from 22 controls.Four cytopathic agents were isolated in the test group, two of which were readily subcultured for at least three successive passages.Three cytopathic agents were recovered in the control group, two of which have been identified as adenovirus type 5 and adenovirus type 3. The unidentified agents tested so far are sensitive to ether and to pH 3. The results of acridine-orange staining and the immunofluorescence technique, using a conjugated control serum and two conjugated convalescent infectious mononucleosis sera, indicate that the isolated agent or agents in the test group are RNA-type agents with a cytoplasmic cycle of development. The overall results of this study lead the authors to suspect a respiratory syncytial-like myxovirus as the as yet unidentified agent which they recovered.
对27例传染性单核细胞增多症（保罗 - 邦内尔 - 大卫 - 索恩试验阳性）患者的咽拭子、直肠拭子及洗涤后的白细胞，以及22名对照者进行了病毒学研究。试验组分离出4种细胞病变因子，其中2种可轻易传代至少连续3代。对照组分离出3种细胞病变因子，其中2种已鉴定为5型腺病毒和3型腺病毒。目前未鉴定出的因子对乙醚和pH 3敏感。使用结合对照血清和两份结合恢复期传染性单核细胞增多症血清进行的吖啶橙染色及免疫荧光技术结果表明，试验组分离出的一种或多种因子是具有细胞质发育周期的RNA型因子。这项研究的总体结果使作者怀疑一种呼吸道合胞体样黏液病毒是他们分离出的尚未鉴定出的因子。
