Joncas J, Lussier G, Pavilanis V
Can Med Assoc J. 1966 Jul 23;95(4):151-4.
Heparinized blood specimens obtained from two patients in the acute phase of infectious mononucleosis and from a healthy technician were injected intravenously into rhesus monkeys (Macaca mulatta) and the animals were observed for three weeks to one month for clinical, hematological and serological signs of infectious mononucleosis.Splenomegaly was the only definite clinical finding after 12 and 16 days, respectively. There were no definite hematological changes.At autopsy, hyperplasia of the germinal centres of lymphoid follicles, occasional foci of lymphocytic infiltration in the red pulp, and abnormal lymphoid cells in venules or arteries of the spleen were noted.The lesions in the spleen suggest that asymptomatic, presumably viral, infections occur in rhesus monkeys after inoculation with material from patients with infectious mononucleosis.
从两名传染性单核细胞增多症急性期患者以及一名健康技术人员身上采集的肝素化血液标本，经静脉注射到恒河猴（猕猴）体内，并对这些动物进行了为期三周至一个月的观察，以寻找传染性单核细胞增多症的临床、血液学和血清学体征。分别在12天和16天后，脾肿大是唯一明确的临床发现。没有明确的血液学变化。尸检时，发现淋巴滤泡生发中心增生，红髓偶尔有淋巴细胞浸润灶，脾脏小静脉或动脉中有异常淋巴细胞。脾脏中的病变表明，恒河猴接种传染性单核细胞增多症患者的材料后会发生无症状的、可能是病毒性的感染。
