Bynum G, Brown J, Dubose D, Marsili M, Leav I, Pistole T G, Hamlet M, LeMaire M, Caleb B
Aviat Space Environ Med. 1979 Aug;50(8):816-9.
A study was undertaken to determine if gut flora contribute to the pathophysiology of experimental canine heatstroke. Fifty animals in four groups were anesthetized with sodium pentobarbital (25 mg/kg) intravenously. An air temperature of 42-46 degrees C was maintained adjacent to the dog with a water-heated blanket for approximately 2 h until rectal temperatures rose to 43.5 +/- 0.4 degrees C. Animals were then cooled passively in room air (28 degrees C, 20% RH) until death or until 18 h elapsed, and were euthanized. Reduction of intestine stool and bacterial contents with antibiotics, cathartics, and enemas prior to heatstroke increased the incidence of 18-h survival from 20.0% to 70.6%; antibiotics administered after heatstroke did not alter the incidence of survival over control values. These data suggest that gut flora, presumably through endotoxemia, contribute to the evolution of heatstroke pathophysiology.
开展了一项研究以确定肠道菌群是否对实验性犬中暑的病理生理学有影响。四组中的五十只动物通过静脉注射戊巴比妥钠（25毫克/千克）进行麻醉。用温水加热毯使犬周围的空气温度保持在42 - 46摄氏度约2小时，直到直肠温度升至43.5±0.4摄氏度。然后将动物在室内空气（28摄氏度，相对湿度20%）中被动冷却，直至死亡或直至18小时过去，随后实施安乐死。在中暑前用抗生素、泻药和灌肠剂减少肠道粪便和细菌含量，使18小时存活率从20.0%提高到70.6%；中暑后给予抗生素并未改变存活率高于对照值的发生率。这些数据表明，肠道菌群可能通过内毒素血症促成中暑病理生理学的发展。
