Bynum G, Patton J, Bowers W, Leav I, Hamlet M, Marsili M, Wolfe D
Aviat Space Environ Med. 1978 Jun;49(6):779-84.
This study was undertaken to compare cooling in room air (27 degrees C, 20% RH), ice slush surface cooling, and peritoneal lavage cooling (6-10 degrees C) as methods for lowering body temperature in an anesthetized dog heatstroke model. We anesthetized 19 animals with sodium pentobarbital (25 mg/kg) intravenously, and maintained them in an ambient temperature of 42-46 degrees C with a water heating blanket approximately 2.0 h until rectal temperatures rose to 43.2 +/- 0.2 degrees C. At the maximum rectal temperature, the heating blankets were removed, and animals were cooled, observed until death occurred or 18 h elapsed, and then sacrificed. The data demonstrate that maximum cooling rates of rectal temperature were: peritoneal lavage, 0.56 degrees C/min; ice slush, 0.11 degrees C/min; and 27 degrees C air cooling, 0.06 degrees C/min. The incidence of 18-h survival for lavage-cooled dogs when supported with normothermic dialysis every 4 h was significantly greater than for either ice slush or air cooled dogs.
本研究旨在比较在室温空气（27摄氏度，相对湿度20%）、冰泥表面冷却和腹腔灌洗冷却（6 - 10摄氏度）作为降低麻醉犬中暑模型体温的方法。我们用戊巴比妥钠（25毫克/千克）静脉麻醉19只动物，并使用水加热毯将它们置于42 - 46摄氏度的环境温度下约2.0小时，直到直肠温度升至43.2±0.2摄氏度。在直肠温度达到最高时，移除加热毯，对动物进行冷却，观察直至死亡或18小时过去，然后处死。数据表明，直肠温度的最大冷却速率为：腹腔灌洗，0.56摄氏度/分钟；冰泥，0.11摄氏度/分钟；27摄氏度空气冷却，0.06摄氏度/分钟。每4小时用常温透析支持时，灌洗冷却犬的18小时生存率显著高于冰泥或空气冷却犬。
