萘啶酸对脱氧核糖核酸噬菌体生长的影响。
Effect of nalidixic acid on the growth of deoxyribonucleic acid bacteriophages.
作者信息
Baird J P, Bourguignon G J, Sternglanz R
出版信息
J Virol. 1972 Jan;9(1):17-21. doi: 10.1128/JVI.9.1.17-21.1972.
Abstract
The effect of nalidixic acid on the growth of various deoxyribonucleic acid (DNA) bacteriophages has been investigated by one-step growth experiments. The Escherichia coli bacteriophages T5, lambda, T7 and phiR are strongly inhibited by nalidixic acid, whereas T4 and T2 are only partially inhibited. The Bacillus subtilis bacteriophages SP82, SP50, and phi29 are relatively unaffected by nalidixic acid. There is no correlation between those bacteriophages which can grow in the presence of nalidixic acid and the presence of an unusual base in the phage DNA.
摘要
通过一步生长实验研究了萘啶酸对各种脱氧核糖核酸（DNA）噬菌体生长的影响。大肠杆菌噬菌体T5、λ、T7和φR受到萘啶酸的强烈抑制，而T4和T2仅受到部分抑制。枯草芽孢杆菌噬菌体SP82、SP50和φ29相对不受萘啶酸的影响。在萘啶酸存在下能够生长的那些噬菌体与噬菌体DNA中存在异常碱基之间没有相关性。
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