Julshamn K, Utne F, Braekkan O R
Acta Pharmacol Toxicol (Copenh). 1977 Nov;41(5):515-24. doi: 10.1111/j.1600-0773.1977.tb02163.x.
The effect of cadmium on tissue concentrations of iron, zinc and copper was studied in male rats. Two littermate groups were fed a stock diet with or without a supplement of 100 microgram cadmium per g. Every three weeks ten animals from each group were sampled and the liver, kidneys, heart, lungs, spleen, testes, muscle, fur, faeces and urine were individually analyzed. Except for the fur, all the other organs showed highly significantly increased levels of cadmium when compared with the control group. The iron levels were significantly depressed in all organs. As the content of the faeces remained unchanged and the urinary excretion showed an increase, it could be concluded that the cadmium supplementation resulted in a depletion of the body stores of iron. The zinc levels showed a significant increase in the liver and testes and a correspondingly significant decrease in the spleen. The levels of copper generally showed no significant changes.
研究了镉对雄性大鼠组织中铁、锌和铜浓度的影响。将两组同窝出生的大鼠分为两组，一组喂食基础饲料，另一组喂食每克添加100微克镉的基础饲料。每三周从每组中抽取10只动物进行采样，并分别对肝脏、肾脏、心脏、肺、脾脏、睾丸、肌肉、皮毛、粪便和尿液进行分析。与对照组相比，除皮毛外，所有其他器官中的镉含量均显著大幅增加。所有器官中的铁含量均显著降低。由于粪便中的含量保持不变，而尿液排泄量增加，因此可以得出结论，补充镉导致体内铁储备减少。肝脏和睾丸中的锌含量显著增加，而脾脏中的锌含量相应显著降低。铜含量总体上没有显著变化。
