尼日利亚血清中的类风湿因子。
Rheumatoid factor in Nigerian sera.
作者信息
Greenwood B M, Muller A S, Valkenburg H A
出版信息
Clin Exp Immunol. 1971 Aug;9(2):161-73.
Abstract
A high prevalence of rheumatoid factor has been found in the sera of apparently healthy inhabitants of two Western Nigerian villages. The prevalence of rheumatoid factor at high titre increased markedly with age. The rheumatoid factor found in the sera of these apparently healthy subjects showed a selective affinity for human γ-globulin rather than rabbit γ-globulin. Rheumatoid factor activity was shown to be restricted to the serum IgM fraction. In one of the two villages a significant correlation was found between the presence of rheumatoid factor at high titre and the presence of IgM malaria antibodies at high titre and the possible role of malaria in the induction of rheumatoid factor formation in these two communities is discussed.
摘要
在尼日利亚西部两个村庄的貌似健康的居民血清中，发现类风湿因子的高流行率。高滴度类风湿因子的流行率随年龄显著增加。在这些貌似健康的受试者血清中发现的类风湿因子对人γ球蛋白显示出选择性亲和力，而非对兔γ球蛋白。类风湿因子活性显示局限于血清IgM部分。在这两个村庄中的一个，发现高滴度类风湿因子的存在与高滴度IgM疟疾抗体的存在之间存在显著相关性，并讨论了疟疾在这两个社区诱导类风湿因子形成中的可能作用。
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