Rowe W P, Pugh W E, Webb P A, Peters C J
J Virol. 1970 Mar;5(3):289-92. doi: 10.1128/JVI.5.3.289-292.1970.
By means of the indirect fluorescent-antibody test, cross serological reactivity was demonstrated between lymphocytic choriomeningitis (LCM) virus and the viruses of the Tacaribe complex. Antisera to all members of the Tacaribe complex reacted with LCM virus; LCM antisera gave significant staining of Amapari virus, but minimal or inconsistent reactions with Tacaribe virus, and no reaction with two other viruses of the Tacaribe complex. A low level cross-reaction was observed in complement fixation tests of Machupo and Pichinde antisera against LCM antigen. Immunization with Tacaribe and Amapari viruses did not protect mice against challenge with LCM virus. Because of the identical appearance of the virions, the sharing of antigens, and the many biological similarities between LCM and the Tacaribe complex viruses, it is proposed that they be considered as constituting a new taxonomic group of viruses.
通过间接荧光抗体试验，证明淋巴细胞性脉络丛脑膜炎（LCM）病毒与塔卡里贝病毒复合群的病毒之间存在交叉血清学反应。针对塔卡里贝病毒复合群所有成员的抗血清都能与LCM病毒发生反应；LCM抗血清能使阿马帕里病毒产生明显的染色反应，但与塔卡里贝病毒的反应较弱或不一致，与塔卡里贝病毒复合群的另外两种病毒则无反应。在马丘波病毒和皮钦德病毒抗血清针对LCM抗原的补体结合试验中观察到低水平的交叉反应。用塔卡里贝病毒和阿马帕里病毒免疫小鼠并不能保护其免受LCM病毒的攻击。由于病毒粒子外观相同、抗原共享以及LCM病毒与塔卡里贝病毒复合群病毒之间存在许多生物学相似性，因此建议将它们视为构成一个新的病毒分类群。
