慢性尿毒症大鼠的碳水化合物代谢

Carbohydrate metabolism in the chronically uremic rat.

作者信息

Mannan A, Noujaim A A, Wiebe L I, Secord D C, Silverberg D S

出版信息

Clin Biochem. 1975 Jun;8(3):194-8. doi: 10.1016/s0009-9120(75)91943-8.

DOI:10.1016/s0009-9120(75)91943-8

Abstract

The glycogen cycle enzymes amylo1,6-glucosidase, glycogen synthetase (I and D forms) and alpha-glucan phosphorylase (a and b forms) have been assayed for activity in skeletal muscle and hepatic tissues of chronically uremic rats. Significant decreases in muscle amylo-1,6-glucosidase (41%), hepatic phosphorylase (30%) and hepatic synthetase D (30%) activities were observed in uremics, as compared to both sham operted and destricted diet intake controls. Changes in phosphorylase "a" to "b" activity ratios and synthetase I to D activity ratios were found in the uremics. The biochemical significance of these alterations are discussed.

摘要

已对慢性尿毒症大鼠骨骼肌和肝组织中的糖原循环酶淀粉-1,6-葡萄糖苷酶、糖原合成酶（I型和D型）以及α-葡聚糖磷酸化酶（a型和b型）的活性进行了测定。与假手术组和限食对照组相比，尿毒症大鼠的肌肉淀粉-1,6-葡萄糖苷酶活性显著降低（41%），肝磷酸化酶活性降低（30%），肝合成酶D活性降低（30%）。在尿毒症大鼠中发现了磷酸化酶“a”与“b”活性比值以及合成酶I与D活性比值的变化。讨论了这些改变的生化意义。