宿主对细菌内毒素血症的防御：正常动物中的机制。
Host defense against bacterial endotoxemia: mechanism in normal animals.
作者信息
Skarnes R C
出版信息
J Exp Med. 1970 Aug 1;132(2):300-16. doi: 10.1084/jem.132.2.300.
Abstract
The present study defines the early response of normal rabbits to the intravenous injection of a single, sublethal dose of endotoxin. Within the first few hours following endotoxin there occurs in the circulating plasma of recipients a decrease in ionized calcium, a threefold increase in the heat-stable, organo-phosphate-resistant esterase level, and a striking increase in the endotoxin-detoxifying capacity. These results are fully consistent with the thesis that circulating plasma represents a principal site of detoxification and that plasma esterases of the nonspecific, carboxylic type are of major concern in defense against circulating endotoxins.
摘要
本研究确定了正常兔子对静脉注射单次亚致死剂量内毒素的早期反应。在内毒素注射后的最初几个小时内，受体循环血浆中的离子钙减少，热稳定、耐有机磷酸盐的酯酶水平增加了三倍，内毒素解毒能力显著增强。这些结果完全符合以下论点：循环血浆是解毒的主要部位，非特异性羧酸型血浆酯酶在抵御循环内毒素方面至关重要。
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本文引用的文献
1
2
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Nature. 1964 May 23;202:811-2. doi: 10.1038/202811a0.
3
NATURE OF THE ENDOTOXIN-INACTIVATING PRINCIPLE IN GUINEA-PIG LIVER.豚鼠肝脏中内毒素灭活原理的性质
J Bacteriol. 1964 Apr;87(4):832-7. doi: 10.1128/jb.87.4.832-837.1964.
4
DENERVATION OF THE ABDOMINAL VISCERA FOR THE TREATMENT OF TRAUMATIC SHOCK.腹部内脏去神经支配治疗创伤性休克
N Engl J Med. 1963 Oct 3;269:709-16. doi: 10.1056/NEJM196310032691401.
5
Characterization of a Cr51-labeled endotoxin and its identification in plasma and urine after parenteral administration.一种铬51标记的内毒素的特性及其在肠胃外给药后在血浆和尿液中的鉴定。
J Exp Med. 1963 Apr 1;117(4):561-71. doi: 10.1084/jem.117.4.561.
6
Effect of endotoxin on simultaneously determined cardiac output and hepatic blood flow in rabbits.内毒素对兔心输出量和肝血流量同步测定的影响。
J Lab Clin Med. 1963 Mar;61:483-93.
7
Pathogenesis of fever.发热的发病机制。
Physiol Rev. 1960 Jul;40:580-646. doi: 10.1152/physrev.1960.40.3.580.
8
In vivo detoxification of endotoxin by the reticuloendothelial system.网状内皮系统对内毒素的体内解毒作用。
J Exp Med. 1960 Dec 1;112(6):1157-66. doi: 10.1084/jem.112.6.1157.
9
Sensitivity of mice to bacterial lipopolysaccharide following alteration of activity of the reticulo-endothelial system.网状内皮系统活性改变后小鼠对细菌脂多糖的敏感性。
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