前列腺素在全身性施瓦茨曼反应发病机制中的作用
Prostaglandins in the pathogenesis of the generalized Shwartzman reaction.
作者信息
Latour J G, Leger-Gauthier C
出版信息
Am J Obstet Gynecol. 1979 Nov 1;135(5):577-80. doi: 10.1016/s0002-9378(16)32979-9.
The GSR induced by a single injection of endotoxin in pregnant rats and cortisone-sensitized rabbits was prevented by bradykinin. The action is mediated by prostaglandins, such as evidenced by: (1) abolition of the effect of bradykinin by aspirin, (2) prevention of the Shwartzman reaction by infusions of PGA2 and PGE1, and (3) sensitization of the normal male rat to the generalized Shwartzman reaction by infusions of PGA2 and PGE1, and (3) sensitization of the normal male rat to the generalized Shwartzman reaction by indomethacin. The mechanism appears to be a neutralization of the essential alpha-adrenergic component of the generalized Shwartzman reaction.
缓激肽可预防单次注射内毒素的孕鼠和经可的松致敏的兔所诱发的全身性施瓦茨曼反应（GSR）。该作用由前列腺素介导，如下所示：（1）阿司匹林可消除缓激肽的作用；（2）输注前列腺素A2（PGA2）和前列腺素E1（PGE1）可预防施瓦茨曼反应；（3）吲哚美辛可使正常雄性大鼠对全身性施瓦茨曼反应敏感。其机制似乎是中和全身性施瓦茨曼反应中必需的α-肾上腺素能成分。
Zotero 插件