Ikeda M, Hosotani T, Ueda T, Kotake Y, Sakakibara B
J Nutr Sci Vitaminol (Tokyo). 1979;25(3):151-8. doi: 10.3177/jnsv.25.151.
The transition of zinc and iron metabolism in vitamin B6 deficiency was investigated using germ-free and conventional rats. In contrast to previous reports, a decrease in zinc content was not observed in the liver, pancreas, kindney, spleen, lung or testes of vitamin B6-deficient conventional and germ-free rats, but we found an increase in zinc content in the kidney of conventional rats and in the liver and spleen of germ-free rats. Vitamin B6-deficient conventional and germ-free rats retained more iron in their tissues than the control animals did, except for the spleen of germ-free rats. The deposit of iron was more evident in vitamin B6-deficient germ-free rats than in vitamin B6-deficient conventional rats, and is possibly proportional to the degree of vitamin B6 deficiency. It is possible that the deposit of iron in the organs had some influence on metabolic disorders in vitamin B6-deficient rats.
利用无菌大鼠和普通大鼠研究了维生素B6缺乏时锌和铁代谢的转变。与之前的报道相反，在维生素B6缺乏的普通大鼠和无菌大鼠的肝脏、胰腺、肾脏、脾脏、肺或睾丸中未观察到锌含量降低，但我们发现普通大鼠肾脏以及无菌大鼠肝脏和脾脏中的锌含量增加。除无菌大鼠的脾脏外，维生素B6缺乏的普通大鼠和无菌大鼠组织中保留的铁比对照动物更多。铁沉积在维生素B6缺乏的无菌大鼠中比在维生素B6缺乏的普通大鼠中更明显，并且可能与维生素B6缺乏的程度成正比。器官中铁的沉积可能对维生素B6缺乏大鼠的代谢紊乱有一定影响。
