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1
Effect of digoxin on human red blood cell electrolytes.地高辛对人体红细胞电解质的影响。
Br J Pharmacol. 1972 Jan;44(1):165-7. doi: 10.1111/j.1476-5381.1972.tb07250.x.
2
[Influence of beta 1-methyl-digoxin to red cell electrolyte contents in healthy normals (author's transl)].
Klin Wochenschr. 1975 Feb 1;53(3):125-8. doi: 10.1007/BF01466715.
3
The kinetics of red blood cell electrolyte alterations following digoxin administration. A report of two pediatric cases.地高辛给药后红细胞电解质变化的动力学。两例儿科病例报告。
Dev Pharmacol Ther. 1981;3(1):50-4. doi: 10.1159/000457420.
4
Changes in red blood cell electrolyte concentrations in digitalis intoxication.洋地黄中毒时红细胞电解质浓度的变化。
Am Heart J. 1983 Jul;106(1 Pt 1):14-20. doi: 10.1016/0002-8703(83)90432-5.
5
Changes in sodium and potassium in human red cells in vivo related to treatment with digoxin, to hypokalemia, and to cell density.
Ann N Y Acad Sci. 1974;242(0):693-702. doi: 10.1111/j.1749-6632.1974.tb19129.x.
6
Relation between plasma and red-cell electrolyte concentrations and digoxin levels in children.儿童血浆及红细胞电解质浓度与地高辛水平的关系
N Engl J Med. 1978 Sep 7;299(10):501-4. doi: 10.1056/NEJM197809072991001.
7
The erythrocyte sodium and potassium in patients treated with digoxin.接受地高辛治疗患者的红细胞钠和钾。
Br J Clin Pharmacol. 1980 Aug;10(2):127-33. doi: 10.1111/j.1365-2125.1980.tb01729.x.
8
Red blood cell electrolytes for monitoring digoxin therapy in adults.用于监测成人地高辛治疗的红细胞电解质。
Ther Drug Monit. 1985;7(2):191-6. doi: 10.1097/00007691-198506000-00009.
9
The effect of hypokalaemia and of digoxin therapy on red cell sodium and potassium content. Some clinical aspects.
Scand J Clin Lab Invest. 1974 Feb;33(1):11-6. doi: 10.3109/00365517409114191.
10
Sodium and potassium in human red cells: variations among centrifuged cells.
Scand J Clin Lab Invest. 1974 May;33(3):231-7. doi: 10.1080/00365517409082491.

引用本文的文献

1
The erythrocyte sodium and potassium in patients treated with digoxin.接受地高辛治疗患者的红细胞钠和钾。
Br J Clin Pharmacol. 1980 Aug;10(2):127-33. doi: 10.1111/j.1365-2125.1980.tb01729.x.
2
[The problem of the cellular receptor for cardiac glycosides (author's transl)].[强心苷的细胞受体问题（作者译）]
Klin Wochenschr. 1981 Dec 15;59(24):1333-43. doi: 10.1007/BF01720553.
3
The early and late effects of digoxin treatment on the sodium transport, sodium content and Na+K+- ATPase or erythrocytes.地高辛治疗对钠转运、钠含量以及红细胞钠钾ATP酶的早期和晚期影响。
Br J Clin Pharmacol. 1981 Jun;11(6):565-70. doi: 10.1111/j.1365-2125.1981.tb01172.x.
4
Sodium-potassium pump, ion fluxes, and cellular dehydration in sickle cell anemia.镰状细胞贫血中的钠钾泵、离子通量与细胞脱水
J Clin Invest. 1987 Jun;79(6):1621-8. doi: 10.1172/JCI112998.
5
Monitoring digoxin therapy: I. Plasma concentrations and an in vitro assay of tissue response.监测地高辛治疗：I. 血浆浓度及组织反应的体外测定
Br J Clin Pharmacol. 1977 Apr;4(2):213-21. doi: 10.1111/j.1365-2125.1977.tb00697.x.
6
Changes in cardiac glycoside receptor sites, 86rubidium uptake and intracellular sodium concentrations in the erythrocytes of patients receiving digoxin during the early phases of treatment of cardiac failure in regular rhythm and of atrial fibrillation.在心力衰竭伴正常节律及心房颤动患者接受地高辛治疗的早期阶段，其红细胞中强心苷受体位点、铷⁸⁶摄取及细胞内钠浓度的变化。
Br J Clin Pharmacol. 1979 Aug;8(2):125-34. doi: 10.1111/j.1365-2125.1979.tb05810.x.

本文引用的文献

1
STUDIES IN CONGESTIVE HEART FAILURE: IX. The Effect of Digitalis on the Potassium Content of the Cardiac Muscle of Dogs.充血性心力衰竭的研究：IX. 洋地黄对犬心肌钾含量的影响。
J Clin Invest. 1931 Apr;10(1):139-44. doi: 10.1172/JCI100334.
2
The permeability of human erythrocytes to sodium.人体红细胞对钠的通透性。
J Physiol. 1951 May;113(4):506-24. doi: 10.1113/jphysiol.1951.sp004591.
3
Membrane adenosine triphosphatase as a participant in the active transport of sodium and potassium in the human erythrocyte.膜三磷酸腺苷酶作为人类红细胞中钠和钾主动转运的参与者。
J Biol Chem. 1960 Jun;235:1796-802.
4
OUABAIN EFFECTS ON CARDIAC CONTRACTION, ACTION POTENTIAL, AND CELLULAR POTASSIUM.哇巴因对心脏收缩、动作电位和细胞钾的影响。
Circ Res. 1965 Jul;17:46-56. doi: 10.1161/01.res.17.1.46.
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Studies on sodium-potassium-activated adenosinetriphosphatase. IV. Correlation with cation transport sensitive to cardiac glycosides.钠钾激活的三磷酸腺苷酶的研究。IV. 与对强心苷敏感的阳离子转运的相关性。
Arch Biochem Biophys. 1962 Sep;98:413-9. doi: 10.1016/0003-9861(62)90206-0.
6
Regulation of cell volume by active cation transport in high and low potassium sheep red cells.高钾和低钾绵羊红细胞中通过主动阳离子转运调节细胞体积
J Gen Physiol. 1960 Sep;44(1):169-94. doi: 10.1085/jgp.44.1.169.
7
Adenosinetriphosphatase activity and the active movements of alkali metal ions.三磷酸腺苷酶活性与碱金属离子的主动转运
J Physiol. 1961 Apr;156(2):274-93. doi: 10.1113/jphysiol.1961.sp006675.
8
The action of cardiac glycosides on sodium and potassium movements in human red cells.强心苷对人体红细胞中钠和钾转运的作用。
J Physiol. 1957 Apr 3;136(1):148-73. doi: 10.1113/jphysiol.1957.sp005749.
9
Sodium and potassium movements in human red cells.人体红细胞中钠和钾的运动
J Physiol. 1956 Nov 28;134(2):278-310. doi: 10.1113/jphysiol.1956.sp005643.
10
The sodium, potassium, and water contents of red blood cells of healthy human adults.健康成年人红细胞中的钠、钾和水含量。
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地高辛对人体红细胞电解质的影响。

Effect of digoxin on human red blood cell electrolytes.

作者信息

Kettlewell M, Nowers A, White R

出版信息

Br J Pharmacol. 1972 Jan;44(1):165-7. doi: 10.1111/j.1476-5381.1972.tb07250.x.

DOI:10.1111/j.1476-5381.1972.tb07250.x
PMID:5015037
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1665685/
Abstract

Red blood cell electrolytes were measured during 48 h after administration of digoxin to twelve patients. The concentrations of some red cell electrolytes changed: sodium increased while potassium decreased significantly. These findings agree with in vitro experiments on red cells and other tissues including myocardium. Change in membrane ATPase activity is probably responsible for the electrolyte changes both in vitro and in vivo.

摘要

在给12名患者服用地高辛后的48小时内测量了红细胞电解质。一些红细胞电解质的浓度发生了变化：钠增加而钾显著减少。这些发现与对红细胞及包括心肌在内的其他组织的体外实验结果一致。膜ATP酶活性的变化可能是体外和体内电解质变化的原因。