在心力衰竭伴正常节律及心房颤动患者接受地高辛治疗的早期阶段，其红细胞中强心苷受体位点、铷⁸⁶摄取及细胞内钠浓度的变化。
Changes in cardiac glycoside receptor sites, 86rubidium uptake and intracellular sodium concentrations in the erythrocytes of patients receiving digoxin during the early phases of treatment of cardiac failure in regular rhythm and of atrial fibrillation.
作者信息
Ford A R, Aronson J K, Grahame-Smith D G, Carver J G
出版信息
Br J Clin Pharmacol. 1979 Aug;8(2):125-34. doi: 10.1111/j.1365-2125.1979.tb05810.x.
Abstract
1 Measurements of the binding of 12-alpha-[3H]-digoxin to the membranes of intact erythrocytes, erythrocytic 86rubidium uptake and intraerythrocytic sodium concentrations have been made in the red cells of patients receiving digoxin in the short-term for atrial fibrillation or cardiac failure in regular rhythm. 2 During the first few days of treatment [3H]-digoxin binding and 86rubidium uptake fall and intraerythrocytic sodium concentrations rise. 3 Subsequently parallel fluctuations occur in [3H]-digoxin binding and 86rubidium uptake but not in intraerythrocytic sodium concentrations and the significance of the fluctuations is discussed. 4 The values of all three measurements correlate significantly with the response of the heart in sinus rhythm as measured by QS2I. 5 Plasma digoxin concentrations do not correlate with QS2I.
摘要
- 对短期接受地高辛治疗的房颤或心律正常的心力衰竭患者的红细胞进行了12-α-[3H]-地高辛与完整红细胞膜结合、红细胞摄取86铷及红细胞内钠浓度的测定。2. 在治疗的最初几天，[3H]-地高辛结合及86铷摄取下降，而红细胞内钠浓度升高。3. 随后，[3H]-地高辛结合及86铷摄取出现平行波动，但红细胞内钠浓度未出现波动，并对这些波动的意义进行了讨论。4. 所有这三项测量值与通过QS2I测量的窦性心律时心脏的反应显著相关。5. 血浆地高辛浓度与QS2I不相关。
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Changes in cardiac glycoside receptor sites, 86rubidium uptake and intracellular sodium concentrations in the erythrocytes of patients receiving digoxin during the early phases of treatment of cardiac failure in regular rhythm and of atrial fibrillation.在心力衰竭伴正常节律及心房颤动患者接受地高辛治疗的早期阶段，其红细胞中强心苷受体位点、铷⁸⁶摄取及细胞内钠浓度的变化。
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