Pb2+离子催化的寡聚腺苷酸的模板导向合成。
Template-directed synthesis of oligoadenylates catalyzed by Pb2+ ions.
作者信息
Sleeper H L, Lohrmann R, Orgel L E
出版信息
J Mol Evol. 1979 Oct;13(3):203-14. doi: 10.1007/BF01739480.
PMID:501744
Abstract
The Pb2+ ion is an effective catalyst for the template-directed condensation of ImpA on poly(U). This reaction generates up to 35% of oligomers 5 or more units long. Furthermore, the product is predominantly 3'-5'-linked (75%) unlike that from the uncatalyzed reaction which is more than 90% 2'-5'-linked. The significance of metal-ion catalysis for prebiotic polynucleotide formation is discussed.
摘要
Pb2+离子是聚（U）上ImpA模板导向缩合反应的有效催化剂。该反应可生成高达35%的长度为5个或更多单元的寡聚物。此外，产物主要是3'-5'-连接的（75%），这与未催化反应的产物不同，未催化反应的产物90%以上是2'-5'-连接的。本文讨论了金属离子催化对益生元多核苷酸形成的意义。
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