免疫耐受：局部淋巴结的作用
Immunologic tolerance: role of the regional lymph node.
作者信息
Friedlaender M H, Baer H
出版信息
Science. 1972 Apr 21;176(4032):312-4. doi: 10.1126/science.176.4032.312.
PMID:5019790
Abstract
Dansyl chloride, a skin setnsitizer when injected in complete Freund's adjuvant, induced marked tolerance and no sensitization when applied to the intact skin of guinea pigs. Application of this chemical to alymphatic skin islands failed to induce tolerance or sensitization. Lymnphatic connections between skin and regional lymph nodes were essential for the developmnent of ismmunologic toleance.
摘要
丹磺酰氯，当与完全弗氏佐剂一起注射时是一种皮肤致敏剂，当应用于豚鼠完整皮肤时会诱导明显的耐受性且不会致敏。将这种化学物质应用于无淋巴的皮肤岛未能诱导耐受性或致敏。皮肤与局部淋巴结之间的淋巴连接对于免疫耐受性的发展至关重要。
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