Feinstein B
Electroencephalogr Clin Neurophysiol. 1975 Jul;39(1):96-99. doi: 10.1016/0013-4694(75)90133-9.
This study investigated changes in the EEG of addicts initially on heroin as they progressed through the induction and maintenance phases of a methadone program. Spectral analysis of bipolar recordings revealed significant consistent differences only in the eyes-closed resting state. Patients under the influence of heroin showed large sharp peaks at 9-10 c/sec, particularly in the parieto-occipital recording. Methadone induction led either to marked reduction of this peak and widening of alpha band activity or to an increase in frequency of the alpha peak to 12 c/sec. After several months of methadone the alpha peak was still absent unless heroin abuse was present, a theta peak was present in three of four patients, and the alpha bandwidth remained broad. Changes in the theta band were more difficult to interpret.
本研究调查了最初使用海洛因的成瘾者在美沙酮治疗方案的诱导期和维持期过程中脑电图（EEG）的变化。对双极记录进行频谱分析发现，仅在闭眼静息状态下存在显著一致的差异。受海洛因影响的患者在9 - 10赫兹处出现大的尖峰，尤其是在顶枕部记录中。美沙酮诱导要么导致该尖峰显著降低以及α波段活动增宽，要么导致α峰频率增加至12赫兹。在使用美沙酮数月后，除非存在海洛因滥用情况，α峰仍然消失，四名患者中有三名出现θ峰，且α带宽仍然较宽。θ波段的变化更难解释。
