Guarnieri G F, Carretta R, Toigo G, Campanacci L
Nephron. 1979;24(5):212-6. doi: 10.1159/000181719.
The metabolic effects of an acute acetate load have been investigated in chronic uremic patients and in controls. The decay rate of blood acetate levels was significantly lower in patients than in controls. Higher levels of blood acetoacetate and 2-oxoglutarate and plasma triglycerides were observed in the patients after the load. No difference was detectable in plasma levels of unesterified fatty acids and cholesterol between the two groups of subjects. Acetate oxidation in citric acid cycle may be reduced in uremia owing to a lack of coenzyme A. These observations raise the possibility that chronic acetate administration with the dialysate induces hypertriglyceridemia and accelerates the development of atherosclerosis in hemodialysis patients.
已经在慢性尿毒症患者和对照组中研究了急性醋酸盐负荷的代谢效应。患者血液中醋酸盐水平的衰减率显著低于对照组。负荷后在患者中观察到血液中乙酰乙酸和2-氧代戊二酸以及血浆甘油三酯的水平更高。两组受试者之间未酯化脂肪酸和胆固醇的血浆水平没有可检测到的差异。由于缺乏辅酶A，尿毒症患者柠檬酸循环中的醋酸盐氧化可能会减少。这些观察结果增加了一种可能性，即通过透析液长期给予醋酸盐会诱发高甘油三酯血症，并加速血液透析患者动脉粥样硬化的发展。
