多肽（聚α-氨基酸）的抗原性。第十五部分。小鼠体内合成多肽免疫原性的研究。
Antigenicity of polypeptides (poly alpha amino acids). XV. Studies on the immunogenicity of synthetic polypeptides in mice.
作者信息
Pinchuck P, Maurer P H
出版信息
J Exp Med. 1965 Oct 1;122(4):665-71. doi: 10.1084/jem.122.4.665.
Abstract
The response of mice to synthetic linear polypeptides of known composition but random sequence has been studied. Neither Swiss mice nor a number of inbred strains could respond to copolymers of only 2 amino acids (G(60)L(40), G(60)A(40), G(90)T(10)). Upon introduction of as little as 4 mole per cent of a third amino acid, good immune responses were obtained, regardless of the nature of the third amino acid. The level of the immune response to a series of glu-lys-ala polymers increased with increasing alanine content of the polymer.
摘要
已对小鼠对已知组成但序列随机的合成线性多肽的反应进行了研究。瑞士小鼠和许多近交系都不能对仅由2种氨基酸组成的共聚物（G(60)L(40)、G(60)A(40)、G(90)T(10)）产生反应。只要引入低至4摩尔百分比的第三种氨基酸，就能获得良好的免疫反应，而不论第三种氨基酸的性质如何。对一系列谷氨酸-赖氨酸-丙氨酸聚合物的免疫反应水平随着聚合物中丙氨酸含量的增加而提高。
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