从用L-谷氨酸60-L-丙氨酸30-L-酪氨酸10（GAT）致敏的无反应小鼠的淋巴细胞中提取的免疫抑制因子II.细胞来源及其对反应小鼠和无反应小鼠的影响
Immunosuppressive factor(s) extracted from lymphoid cells of nonresponder mice primed with L-glutamic acid60-L-alanine30-L-tyrosine10 (GAT) II. Cellular source and effect on responder and nonresponder mice.
作者信息
Kapp J A, Pierce C W, Benacerraf B
出版信息
J Exp Med. 1977 Apr 1;145(4):828-38. doi: 10.1084/jem.145.4.828.
Abstract
The synthetic terpolymer of L-glutamic acid60-L-alanine30-L-tyrosine10 (GAT) fails to stimulate development of GAT-specific antibody responses in nonresponder strains of mice, but does stimulate the development of GAT-specific suppressor T cells that inhibit the development of normal anti-GAT antibody responses to GAT complexed to methylated bovine serum albumin (GAT-MBSA). Furthermore, extracts prepared from lymphoid cells of GAT-primed, but not control, nonresponder mice inhibit the development of antibody responses to GAT-MBSA by normal nonresponder mice. This suppression is specific, dose-dependent, and can be readily analyzed in vitro. The suppressive factor is a T-cell product. An extract from GAT-primed DBA/1 mice inhibits the response to GAT-MBSA by spleen cells from histoincompatible strains of mice that are nonresponders to GAT, but not strains that are responders to GAT.
摘要
L-谷氨酸60-L-丙氨酸30-L-酪氨酸10（GAT）的合成三元共聚物无法刺激无反应小鼠品系中GAT特异性抗体反应的发展，但确实能刺激GAT特异性抑制性T细胞的发展，这些抑制性T细胞会抑制正常小鼠对与甲基化牛血清白蛋白复合的GAT（GAT-MBSA）产生抗GAT抗体反应。此外，从经GAT免疫的无反应小鼠而非对照无反应小鼠的淋巴细胞中制备的提取物，会抑制正常无反应小鼠对GAT-MBSA的抗体反应的发展。这种抑制是特异性的、剂量依赖性的，并且可以在体外轻松分析。抑制因子是一种T细胞产物。来自经GAT免疫的DBA/1小鼠的提取物，会抑制来自与GAT无反应的组织不相容小鼠品系的脾细胞对GAT-MBSA的反应，但不会抑制对GAT有反应的品系的反应。
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