流感病毒核糖核酸基因组由病毒粒子聚合酶进行转录。3.转录过程的完整性。
Transcription of the influenza ribonucleic acid genome by a virion polymerase. 3. Completeness of the transcription process.
作者信息
Bishop D H, Roy P, Bean W J, Simpson R W
出版信息
J Virol. 1972 Oct;10(4):689-97. doi: 10.1128/JVI.10.4.689-697.1972.
Abstract
The virion ribonucleic acid (RNA) polymerase of influenza strain A(0)/WS transcribed at least 81% of the viral genome in vitro. The polymerase is shown to be associated with each of the major size classes of the virion RNA-ribonucleoprotein complexes. Under optimal in vitro conditions, at least 45% of the RNA contained in a population of influenza virions was involved in a repetitive transcription process. The detectable proteins associated with enzymatically active complexes containing RNA, ribonucleoprotein, and polymerase have been identified by polyacrylamide gel electrophoresis.
摘要
甲型流感病毒A(0)/WS毒株的病毒粒子核糖核酸（RNA）聚合酶在体外转录了至少81%的病毒基因组。该聚合酶与病毒粒子RNA-核糖核蛋白复合物的每个主要大小类别相关。在最佳体外条件下，一群流感病毒粒子中所含的RNA至少45%参与了重复转录过程。通过聚丙烯酰胺凝胶电泳已鉴定出与含有RNA、核糖核蛋白和聚合酶的酶活性复合物相关的可检测蛋白质。
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