Penhoet E, Miller H, Doyle M, Blatti S
Proc Natl Acad Sci U S A. 1971 Jun;68(6):1369-71. doi: 10.1073/pnas.68.6.1369.
An RNA-dependent RNA polymerase activity has been detected in purified preparations of influenza virus. In contrast to the replicase activity induced in influenza-infected cells, the virion-associated enzyme has an absolute requirement for Mn(++). Most of the RNA synthesized in vitro is complementary to virion RNA.
在流感病毒的纯化制剂中检测到了一种依赖RNA的RNA聚合酶活性。与流感病毒感染细胞中诱导产生的复制酶活性不同,病毒体相关酶对Mn(++)有绝对需求。体外合成的大部分RNA与病毒体RNA互补。