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对尼古丁中枢抑制作用产生耐受性的情况。

The occurrence of tolerance to a central depressant effect of nicotine.

作者信息

Morrison C F, Stephenson J A

出版信息

Br J Pharmacol. 1972 Sep;46(1):151-6. doi: 10.1111/j.1476-5381.1972.tb06857.x.

DOI:10.1111/j.1476-5381.1972.tb06857.x
PMID:5084817
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1666121/
Abstract
  1. Rats were injected with 0.8 mg nicotine/kg, 0.8 mg amphetamine/kg or with saline immediately before being tested for 30 min in activity boxes.2. During the first 3 trials the nicotine group were less active than the controls but from trial 5 onwards nicotine had a stimulant effect. The stimulant effect of the amphetamine did not alter with repeated injection.
摘要

  1. 在将大鼠放入活动箱进行30分钟测试之前，立即给它们注射0.8毫克/千克尼古丁、0.8毫克/千克苯丙胺或生理盐水。

  2. 在最初的3次试验中，尼古丁组的活动量低于对照组，但从第5次试验开始，尼古丁产生了刺激作用。苯丙胺的刺激作用不会因重复注射而改变。

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The occurrence of tolerance to a central depressant effect of nicotine.对尼古丁中枢抑制作用产生耐受性的情况。
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The effects of nicotine on locomotor activity in non-tolerant and tolerant rats.尼古丁对非耐受性和耐受性大鼠运动活动的影响。
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Effects of nicotine on spontaneous and amphetamine-induced motor behaviors: the differences between nicotine tolerant and nontolerant rats.尼古丁对自发及苯丙胺诱导的运动行为的影响：尼古丁耐受和非耐受大鼠之间的差异。
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Effects of nicotine, caffeine, and their combination on locomotor activity in rats.尼古丁、咖啡因及其组合对大鼠运动活动的影响。
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Nicotine treatment produces persistent increases in amphetamine-stimulated locomotor activity in periadolescent male but not female or adult male rats.尼古丁治疗会使青春期前后的雄性大鼠而非雌性或成年雄性大鼠在苯丙胺刺激下的运动活性持续增加。
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Caffeine and amphetamine produce cross-sensitization to nicotine-induced locomotor activity in mice.咖啡因和苯丙胺对尼古丁诱导的小鼠运动活动产生交叉致敏作用。
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本文引用的文献

1
The measurement of the influence of drugs on voluntary activity in mice.药物对小鼠自发活动影响的测定。
Br J Pharmacol Chemother. 1953 Mar;8(1):46-8. doi: 10.1111/j.1476-5381.1953.tb00749.x.
2
A comparison of the effects of nicotine and amphetamine on DRL performance in the rat.
Psychopharmacologia. 1968;12(2):176-80. doi: 10.1007/BF00401548.
3
The modification by physostigmine of some effects of nicotine on bar-pressing behaviour of rats.毒扁豆碱对尼古丁对大鼠压杆行为某些影响的修饰作用。
Br J Pharmacol Chemother. 1968 Jan;32(1):28-33. doi: 10.1111/j.1476-5381.1968.tb00426.x.
4
The effects of nicotine on punished behaviour.
Psychopharmacologia. 1969;14(3):221-32. doi: 10.1007/BF00404220.
5
Antagonism by antimuscarinic and ganglion-blocking drugs of some of the behavioural effects of nicotine.抗毒蕈碱药和神经节阻断药对尼古丁某些行为效应的拮抗作用。
Psychopharmacologia. 1969;15(5):341-50. doi: 10.1007/BF00403709.