对尼古丁中枢抑制作用产生耐受性的情况。
The occurrence of tolerance to a central depressant effect of nicotine.
作者信息
Morrison C F, Stephenson J A
出版信息
Br J Pharmacol. 1972 Sep;46(1):151-6. doi: 10.1111/j.1476-5381.1972.tb06857.x.
Abstract
- Rats were injected with 0.8 mg nicotine/kg, 0.8 mg amphetamine/kg or with saline immediately before being tested for 30 min in activity boxes.2. During the first 3 trials the nicotine group were less active than the controls but from trial 5 onwards nicotine had a stimulant effect. The stimulant effect of the amphetamine did not alter with repeated injection.
摘要
在将大鼠放入活动箱进行30分钟测试之前，立即给它们注射0.8毫克/千克尼古丁、0.8毫克/千克苯丙胺或生理盐水。
在最初的3次试验中，尼古丁组的活动量低于对照组，但从第5次试验开始，尼古丁产生了刺激作用。苯丙胺的刺激作用不会因重复注射而改变。
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