Vassalli J D, Reich E
J Exp Med. 1977 Feb 1;145(2):429-37. doi: 10.1084/jem.145.2.429.
Macrophages obtained from the peritoneal cavity of untreated mice do not ordinarily synthesize plasminogen activator. However, induction of enzyme synthesis and secretion occurs when such macrophages are cultured in presence of conditioned medium from Con A-stimulated spleen cells. Plasminogen activator production by macrophages from endotoxin or thioglycollate medium-injected mice, which spontaneously secrete substantial amounts of the enzyme, is also markedly increased in presence of such conditioned medium. These results suggest that macrophage plasminogen activatory production may be regulated in part by lymphocytes. They provide further evidence to link macrophage plasminogen activator with cell migration and inflammation, and also support the view that in macrophages, as in certain other cell types, synthesis and secretion of this enzyme are under hormonal control.
从未经处理的小鼠腹腔中获取的巨噬细胞通常不合成纤溶酶原激活物。然而，当这些巨噬细胞在来自刀豆球蛋白A刺激的脾细胞的条件培养基存在下培养时，会诱导酶的合成和分泌。内毒素或巯基乙酸盐培养基注射小鼠的巨噬细胞会自发分泌大量该酶，在这种条件培养基存在下，其纤溶酶原激活物的产生也会显著增加。这些结果表明，巨噬细胞纤溶酶原激活物的产生可能部分受淋巴细胞调节。它们进一步证明了巨噬细胞纤溶酶原激活物与细胞迁移和炎症之间的联系，也支持了这样一种观点，即与某些其他细胞类型一样，巨噬细胞中这种酶的合成和分泌受激素控制。
