Wannenmacher M, Esser E, Schumann J
Strahlentherapie. 1975 Feb;149(2):131-40.
On the Ehrlich-ascites tumor and on the solide Ehrlich carcinoma of the mouse, bleomycin causes a large fixation in the (G2+M)-phase of the cell cycle of the tumor cells. Even in certain human solide tumors, after the application of bleomycin in a predetermined period an increase of the G2 portion of the proliferating cells can be observed. By individual control which can be peraformed rapidly and with high accuracy by impulse cytophotometry, this partial synchronisation effect can be used for radiotherapy.
对于小鼠艾氏腹水瘤和实体艾氏癌，博来霉素可使肿瘤细胞的细胞周期在（G2 + M）期大量停滞。即使在某些人类实体瘤中，在预定时间段内应用博来霉素后，也可观察到增殖细胞中G2部分增加。通过脉冲细胞光度法能够快速且高精度地进行个体控制，这种部分同步化效应可用于放射治疗。
