Rausch P G, Herion J C, Carney C N, Weinstein P
Cancer. 1979 Dec;44(6):2158-64. doi: 10.1002/1097-0142(197912)44:6<2158::aid-cncr2820440628>3.0.co;2-1.
A 25-year-old black female presented with lymphadenopathy, fever and anemia of two months duration. The diagnosis of malignant histiocytosis was made on the basis of histiocytic infiltrations in the sinuses of spleen, liver and lymph nodes and by the demonstration of erythrophagocytosis in bone marrow. Following splenectomy, the patient developed a leukemic phase with as many as 50 X 10(9) abnormal histiocytes/l and bone marrow necrosis. This patient was also atypical because of multiple granulomas in liver, spleen and lymph nodes. Cytochemical and immunofluorescent stains confirmed that the abnormal cells were derived from the monocyte-macrophage series. Electron microscopy was used to further characterize this abnormal cell population. The electron microscopic and cytochemical evidence confirms that the malignant cells in malignant histiocytosis are derived from monocytes.
一名25岁的黑人女性出现淋巴结病、发热和持续两个月的贫血。根据脾、肝和淋巴结窦中的组织细胞浸润以及骨髓中红细胞吞噬现象的证实，诊断为恶性组织细胞增多症。脾切除术后，患者进入白血病期，每升血液中异常组织细胞多达50×10⁹个，并有骨髓坏死。该患者还具有非典型性，因为肝、脾和淋巴结中有多个肉芽肿。细胞化学和免疫荧光染色证实异常细胞来源于单核细胞-巨噬细胞系列。电子显微镜用于进一步表征这种异常细胞群体。电子显微镜和细胞化学证据证实恶性组织细胞增多症中的恶性细胞来源于单核细胞。
