van Wijk R, van de Poll K W
Cell Tissue Kinet. 1979 Nov;12(6):659-63. doi: 10.1111/j.1365-2184.1979.tb00184.x.
Time-lapse cinematographic analysis of a clone of HTC rat hepatoma cells showed variations in interdivision time within the clone. A positive correlation was found between the interdivision times of mother and daughter cells. The variability of the differences between interdivision times of cells of sister, cousin, second cousin or second-second cousin relationship was calculated. The proportion of cells with large differences in intermitotic times was found to increase with decreasing relationship. The clonal division pattern observed suggests strongly that 'inherited' factors goven the process leading to cell division but that their effects can be modified.
对HTC大鼠肝癌细胞克隆进行的延时电影摄影分析显示，该克隆内细胞的分裂间期存在差异。母细胞和子细胞的分裂间期之间呈正相关。计算了姐妹、堂亲、第二代堂亲或第二代第二代堂亲关系的细胞分裂间期差异的变异性。发现有丝分裂间期差异较大的细胞比例随着亲缘关系的降低而增加。观察到的克隆分裂模式有力地表明，“遗传”因素控制着导致细胞分裂的过程，但其作用可以被改变。
