Conner M K, Alarie Y, Dombroske R L
Chromosoma. 1979 Sep 1;74(1):51-5. doi: 10.1007/BF00344482.
Differential labeling of sister chromatids was achieved simultaneously in murine alveolar macrophages, regenerating liver, and bone marrow cells of partially hepatectomized mice as well as in alveolar macrophages and bone marrow cells of nonhepatectomized mice. The mean frequency of SCE/cell +/-S.D. and the percentage of second division cells for each cell type were determined. No significant differences in mean frequencies of SCE/cell were observed among the cell types or between hepatectomized (alveolar macrophages--3.6+/-2.2, bone marrow--3.4+/-2.2; regenerating liver--3.6+/-2.4) and nonhepatectomized (alveolar macrophages--3.4+/-1.9; bone marrow--2.9+/-1.8). Although the percentage of second division cells was dependent upon cell type, no significant differences were apparent between hepatectomized (alveolar macrophages--57+/-8%; bone marrow--37+/-6%; regenerating liver--65+/-6%) and nonhepatectomized mice )alveolar macrophages--53+/-6%; bone marrow--36+/-4%). Comparisons between BrdU treated and nontreated nonhepatectomized mice revealed no significant alteration in mitotic yields.
在部分肝切除小鼠的肺泡巨噬细胞、再生肝脏和骨髓细胞以及未肝切除小鼠的肺泡巨噬细胞和骨髓细胞中，同时实现了姐妹染色单体的差异标记。测定了每种细胞类型的平均SCE/细胞频率±标准差以及第二次分裂细胞的百分比。在不同细胞类型之间，以及肝切除组（肺泡巨噬细胞——3.6±2.2，骨髓——3.4±2.2；再生肝脏——3.6±2.4）和未肝切除组（肺泡巨噬细胞——3.4±1.9；骨髓——2.9±1.8）之间，未观察到SCE/细胞平均频率的显著差异。尽管第二次分裂细胞的百分比取决于细胞类型，但肝切除小鼠（肺泡巨噬细胞——57±8%；骨髓——37±6%；再生肝脏——65±6%）和未肝切除小鼠（肺泡巨噬细胞——53±6%；骨髓——36±4%）之间没有明显的显著差异。对经BrdU处理和未处理的未肝切除小鼠的比较显示，有丝分裂产量没有显著变化。
