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个体虚弱程度的异质性对死亡率动态变化的影响。

The impact of heterogeneity in individual frailty on the dynamics of mortality.

作者信息

Vaupel J W, Manton K G, Stallard E

出版信息

Demography. 1979 Aug;16(3):439-54.

PMID:510638
Abstract

Life table methods are developed for populations whose members differ in their endowment for longevity. Unlike standard methods, which ignore such heterogeneity, these methods use different calculations to construct cohort, period, and individual life tables. The results imply that standard methods overestimate current life expectancy and potential gains in life expectancy from health and safety interventions, while underestimating rates of individual aging, past progress in reducing mortality, and mortality differentials between pairs of populations. Calculations based on Swedish mortality data suggest that these errors may be important, especially in old age.

摘要

生命表方法是针对其成员在长寿禀赋方面存在差异的人群而开发的。与忽略这种异质性的标准方法不同,这些方法使用不同的计算来构建队列、时期和个体生命表。结果表明,标准方法高估了当前的预期寿命以及健康和安全干预措施在预期寿命方面的潜在收益,同时低估了个体衰老率、过去在降低死亡率方面取得的进展以及不同人群之间的死亡率差异。基于瑞典死亡率数据的计算表明,这些误差可能很重要,尤其是在老年人群中。

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本文引用的文献

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A random-walk model of human mortality and aging.人类死亡率与衰老的随机游走模型。
Theor Popul Biol. 1977 Feb;11(1):37-48. doi: 10.1016/0040-5809(77)90005-3.
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Compartment model approach to the estimation of tumor incidence and growth: investigation of a model of cancer latency.基于房室模型方法估计肿瘤发病率和生长情况:癌症潜伏期模型的研究
Biometrics. 1978 Sep;34(3):377-89.
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Improving life expectancy: an uphill road ahead.提高预期寿命:前路艰难。
应用于医学数据的多元共享截断正态脆弱性模型。
Sci Rep. 2025 Aug 17;15(1):30099. doi: 10.1038/s41598-025-15903-y.
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Sex Differences in Frailty in Milan Over the Last 2000 Years: A Hazards-Based and Cumulative Phenotype Approach.过去2000年米兰衰弱情况中的性别差异:基于风险和累积表型的方法
Am J Biol Anthropol. 2025 Aug;187(4):e70111. doi: 10.1002/ajpa.70111.
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Estimating latent individual demographic heterogeneity using structural equation models.使用结构方程模型估计潜在的个体人口统计学异质性。
Ecology. 2025 Aug;106(8):e70161. doi: 10.1002/ecy.70161.
6
Cave adaptation favors aging resilience in the Mexican tetra.洞穴适应有利于墨西哥丽脂鲤的衰老恢复力。
NPJ Metab Health Dis. 2025 Aug 1;3(1):33. doi: 10.1038/s44324-025-00069-y.
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Analyzing factors affecting age at first birth among married women in Somalia: a Bayesian shared frailty modelling approach using SDHS 2020.分析索马里已婚妇女初育年龄的影响因素:使用2020年索马里人口与健康调查的贝叶斯共享脆弱性建模方法
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Proc Natl Acad Sci U S A. 2025 Jun 10;122(23):e2408163122. doi: 10.1073/pnas.2408163122. Epub 2025 Jun 6.
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Maximum likelihood estimation of a stochastic compartment model of cancer latency: lung cancer mortality among white females in the U.S.癌症潜伏期随机隔室模型的最大似然估计:美国白人女性的肺癌死亡率
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