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免疫后血小板缺乏血浆中肝素中和活性的变化。

Changes in the heparin neutralising activity of platelet poor plasma after immunisation.

作者信息

Baker I A, Howells C H, O'Brien J R

出版信息

J Clin Pathol. 1979 Nov;32(11):1152-4. doi: 10.1136/jcp.32.11.1152.

Abstract

Acute myocardial disease, which may be associated with abnormal platelet activity, has been reported after routine immunisation. Thirty-two army apprentices undergoing immunisation were studied for changes in the heparin neutralising activity (HNA) of platelet poor plasma. HNA increased after immunisation. This increase in HNA may represent an increase in platelet activation but may also relate to changes in acute phase proteins. These changes were not observed in elderly subjects undergoing immunisation with influenza vaccine.

摘要

据报道,常规免疫接种后可能会出现与血小板活性异常相关的急性心肌疾病。对32名接受免疫接种的军校学员进行了研究,以观察无血小板血浆中肝素中和活性(HNA)的变化。免疫接种后HNA升高。HNA的这种升高可能代表血小板活化增加,但也可能与急性期蛋白的变化有关。在接受流感疫苗免疫接种的老年受试者中未观察到这些变化。

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