炎症性肠病中的体液免疫系统：I. 补体水平。
Humoral immune system in inflammatory bowel disease: I. Complement levels.
作者信息
Hodgson H J, Potter B J, Jewell D P
出版信息
Gut. 1977 Sep;18(9):749-53. doi: 10.1136/gut.18.9.749.
Abstract
Serum levels of complement components Clq, C4, C3, and Properdin factor B, from the classical and alternative pathways of complement activation, have been estimated in patients with ulcerative colitis and Crohn's disease. C3, factor B, and to some extent C4 concentrations all increased when the disease was active. In remission the levels of these components did not differ from hospital control patients. There was no evidence for the preferential consumption of the proteins of either pathway of activation, even in those patients with evidence of circulating immune complexes.
摘要
对溃疡性结肠炎和克罗恩病患者补体激活经典途径和替代途径中的补体成分C1q、C4、C3和备解素B因子的血清水平进行了评估。疾病活动期时，C3、B因子以及在一定程度上C4的浓度均升高。缓解期时，这些成分的水平与医院对照患者无异。即使在那些有循环免疫复合物证据的患者中，也没有证据表明任一激活途径的蛋白质存在优先消耗。
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