Shortridge K F, Osmund I F
J Hyg (Lond). 1979 Dec;83(3):397-403. doi: 10.1017/s002217240002622x.
The seroepidemiology of rubella infection in Hong Kong Chinese was examined by haemagglutination inhibition of normal sera and a comparison made where feasible with Caucasians living in Hong Kong. Taking reciprocal titre of 20 as a baseline, the incidence of maternally acquired antibody was 84% for Chinese and 90% for Caucasians. In babies up to 2 months this incidence was maintained in Caucasians but declined to 54% in Chinese. High titre antibody was more frequently detected in Caucasians generally, including women of child-bearing age. The detection of rubella-specific IgM in the Caucasian babies was suggestive of recent maternal infection. However, fewer Caucasian (20%) than Chinese (36%) women of child-bearing age (15-40 years) appeared unprotected against rubella. When all age groups were considered, 88% of Caucasians and 53% of Chinese were seropositive. The occurrence of a rubella outbreak during the study did not give rise to a significant increase in the incidence of seropositivity in Chinese 19-25 years, the only age group able to be evaluated in this manner. The ethnic differences in seroepidemiology are considered in the light of known HLA-1 and HLA-8 antigen distributions in Caucasian and Mongoloid people and the apparently low incidence of congenitally acquired rubella in Chinese.
通过对正常血清进行血凝抑制试验，研究了香港华人风疹感染的血清流行病学情况，并在可行的情况下与居住在香港的高加索人进行了比较。以20的倒数滴度作为基线，华人母体获得抗体的发生率为84%，高加索人为90%。在2个月以下的婴儿中，高加索人的这一发生率保持不变，但华人降至54%。一般来说，在包括育龄妇女在内的高加索人中，更频繁地检测到高滴度抗体。在高加索婴儿中检测到风疹特异性IgM提示近期有母体感染。然而，未受风疹保护的育龄（15 - 40岁）高加索妇女（20%）比华人妇女（36%）少。当考虑所有年龄组时，88%的高加索人和53%的华人血清呈阳性。在研究期间发生的风疹疫情并未使19 - 25岁华人（唯一能够以这种方式评估的年龄组）的血清阳性发生率显著增加。根据已知的高加索人和蒙古人种中HLA - 1和HLA - 8抗原分布情况以及华人中先天性风疹的明显低发病率，对血清流行病学中的种族差异进行了考量。
