Muramatsu T, Schmid H H
J Lipid Res. 1971 Nov;12(6):740-6.
1,2-Heptadecanediol-2-(14)C was administered intracerebrally to 18-day-old rats, and its incorporation, after 8 hr, into the individual aliphatic moieties of the ethanolamine glycerophosphatides was determined. Much of the radioactivity was found in a lipid fraction identified as 1-O-2'-hydroxyheptadecyl glycerol. Evidence is presented that a major portion of the precursor was incorporated into 1-O-2'-hydroxyheptadecyl-2-acyl ethanolamine phosphatides. Some of the diol administered was degraded to palmitic acid. The palmitic acid-1-(14)C derived from 1,2-heptadecanediol-2-(14)C apparently served as precursor for stearic and oleic acids, which were found as acyl groups, and for the biosynthesis of the corresponding O-alkyl and O-alk-1-enyl glycerols. The data presented prove that biological dehydration of 1-O-2'-hydroxyalkyl glycerophosphatides to the corresponding plasmalogens does not occur in myelinating brain.
将1,2 - 十七烷二醇 - 2 -（14）C 脑内注射给18日龄大鼠，8小时后测定其掺入乙醇胺甘油磷脂各个脂肪族部分的情况。在一个鉴定为1 - O - 2'- 羟基十七烷基甘油的脂质部分中发现了大量放射性。有证据表明，大部分前体掺入了1 - O - 2'- 羟基十七烷基 - 2 - 酰基乙醇胺磷脂中。所给予的二醇部分降解为棕榈酸。源自1,2 - 十七烷二醇 - 2 -（14）C 的棕榈酸 - 1 -（14）C 显然作为硬脂酸和油酸的前体，这两种酸以酰基形式存在，并用于相应O - 烷基和O - 烯基甘油的生物合成。所呈现的数据证明，在髓鞘形成的脑内，1 - O - 2'- 羟烷基甘油磷脂不会生物脱水形成相应的缩醛磷脂。
