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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Greenburg A G, Elia C, Levine B, Belsha J, Peskin G W

J Trauma. 1975 Nov;15(11):943-50. doi: 10.1097/00005373-197511000-00001.

A study was carried out to determine the oxyhemoglobin dissociation curve of stroma-free hemoglobin solution and factors which influence it, (pH; 2,3 DPG). 2) To simulate acute volume replacement, dilution experiments, in vitro, were performed employing both hemoglobin solution and Ringer's lactate in whole blood. 3) It was determined that stroma-free hemoglobin solution has a left-shifted oxyhemoglobin dissociation curve which responds to pH change but not to the addition of 2,3 DPG. 4) The dilutional effect of hemoglobin solution when mixed with whole blood in volumes up to 50% was to left-shift the oxyhemoglobin curve, unlike the effect of Ringer's lactate (no change). 5) This may have importance in the hemodynamic compensatory response to acute normovolemic anemia.

开展了一项研究，以确定无基质血红蛋白溶液的氧合血红蛋白解离曲线及其影响因素（pH值；2,3-二磷酸甘油酸）。2) 为模拟急性容量补充，在体外进行了稀释实验，同时使用血红蛋白溶液和全血中的乳酸林格液。3) 已确定无基质血红蛋白溶液的氧合血红蛋白解离曲线向左移位，该曲线对pH值变化有反应，但对添加2,3-二磷酸甘油酸无反应。4) 当血红蛋白溶液与全血混合至体积比达50%时，其稀释作用会使氧合血红蛋白曲线向左移位，这与乳酸林格液的作用不同（无变化）。5) 这可能对急性正常血容量性贫血的血流动力学代偿反应具有重要意义。

Greenburg A G, Elia C, Levine B, Belsha J, Peskin G W

J Trauma. 1975 Nov;15(11):943-50. doi: 10.1097/00005373-197511000-00001.

A study was carried out to determine the oxyhemoglobin dissociation curve of stroma-free hemoglobin solution and factors which influence it, (pH; 2,3 DPG). 2) To simulate acute volume replacement, dilution experiments, in vitro, were performed employing both hemoglobin solution and Ringer's lactate in whole blood. 3) It was determined that stroma-free hemoglobin solution has a left-shifted oxyhemoglobin dissociation curve which responds to pH change but not to the addition of 2,3 DPG. 4) The dilutional effect of hemoglobin solution when mixed with whole blood in volumes up to 50% was to left-shift the oxyhemoglobin curve, unlike the effect of Ringer's lactate (no change). 5) This may have importance in the hemodynamic compensatory response to acute normovolemic anemia.

开展了一项研究，以确定无基质血红蛋白溶液的氧合血红蛋白解离曲线及其影响因素（pH值；2,3-二磷酸甘油酸）。2) 为模拟急性容量补充，在体外进行了稀释实验，同时使用血红蛋白溶液和全血中的乳酸林格液。3) 已确定无基质血红蛋白溶液的氧合血红蛋白解离曲线向左移位，该曲线对pH值变化有反应，但对添加2,3-二磷酸甘油酸无反应。4) 当血红蛋白溶液与全血混合至体积比达50%时，其稀释作用会使氧合血红蛋白曲线向左移位，这与乳酸林格液的作用不同（无变化）。5) 这可能对急性正常血容量性贫血的血流动力学代偿反应具有重要意义。