小鼠脾细胞表面和分泌型 IgM 的电泳差异。
An electrophoretic difference between surface and secreted IgM of murine splenocytes.
作者信息
Melcher U, Uhr J W
出版信息
J Exp Med. 1973 Nov 1;138(5):1282-7. doi: 10.1084/jem.138.5.1282.
Abstract
micro-chains on the surface of murine splenocytes are more heterogeneous on SDS-polyacrylamide gel electrophoresis than both secreted and intracellular micro-chains labeled with [(3)H]tyrosine. No difference in heterogeneity among cell surface, secreted, or intracellular L chains was detected. The possible role of carbohydrate in micro-chain heterogeneity is discussed.
摘要
与用[³H]酪氨酸标记的分泌型和细胞内微链相比，小鼠脾细胞表面的微链在十二烷基硫酸钠-聚丙烯酰胺凝胶电泳上的异质性更高。未检测到细胞表面、分泌型或细胞内轻链之间在异质性上的差异。本文讨论了碳水化合物在微链异质性中的可能作用。
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Immunogenetics. 1978 Dec;7(1):1-12. doi: 10.1007/BF01843981.
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Density comparisons of heavy chains of membrane and secreted immunoglobulins of mouse.小鼠膜结合型和分泌型免疫球蛋白重链的密度比较。
Biochem J. 1979 Nov 1;183(2):395-403. doi: 10.1042/bj1830395.
本文引用的文献
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Immunoglobulin biosynthesis. IV. Carbohydrate attachment to immunoglobulin subunits.免疫球蛋白的生物合成。IV. 碳水化合物与免疫球蛋白亚基的连接。
J Mol Biol. 1970 Jul 28;51(2):287-301. doi: 10.1016/0022-2836(70)90143-9.
2
Intracellular events underlying synthesis and secretion of immunoglobulin.免疫球蛋白合成与分泌的细胞内事件。
Cell Immunol. 1970 Jul;1(2):228-44. doi: 10.1016/0008-8749(70)90010-9.
3
Immunoglobulin synthesis and secretion, IV. Sites of incorporation of sugars as determined by subcellular fractionation.免疫球蛋白的合成与分泌，IV. 通过亚细胞分级分离法确定糖的掺入位点。
Proc Natl Acad Sci U S A. 1970 Jul;66(3):952-8. doi: 10.1073/pnas.66.3.952.
4
Biosynthesis of the carbohydrate portions of immunoglobulin M.免疫球蛋白M碳水化合物部分的生物合成
Biochem J. 1971 Nov;125(1):235-40. doi: 10.1042/bj1250235.
5
Lymphocyte membrane dynamics. Metabolic release of cell surface proteins.淋巴细胞膜动力学。细胞表面蛋白的代谢释放。
J Exp Med. 1971 Dec 1;134(6):1373-84. doi: 10.1084/jem.134.6.1373.
6
The peroxidase-catalyzed oxidation of tyrosine.过氧化物酶催化的酪氨酸氧化。
Biochim Biophys Acta. 1972 Sep 19;284(1):34-42. doi: 10.1016/0005-2744(72)90043-5.
7
Cell surface immunoglobulin. V. Release from murine splenic lymphocytes.细胞表面免疫球蛋白。V. 从小鼠脾淋巴细胞中释放
J Exp Med. 1972 Oct 1;136(4):676-96. doi: 10.1084/jem.136.4.676.
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Variation and homology in imunoglobulin heavy chains.免疫球蛋白重链的变异与同源性。
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