Sacher M, Eder G, Bianchi L, Gudat F, Thaler H
Wien Klin Wochenschr. 1979 Nov 9;91(21):722-6.
372 children with suspected liver disease were examined for serum HBsAg. Six (three boys, three girls) were found to be positive (1.6%). Further studies of these patients for up to three and a half years revealed elimination of HBsAg in one case only. Biopsies were performed in five patients. Three showed mild chronic hepatitis (two chronic persistent hepatitis, one unspecific reactive hepatitis). Chronic aggressive hepatitis was diagnosed in one patient. One child seemed to be normal on light microscopy, but the findings on electron microscopy were abnormal, the liver cell nuclei being filled with core particles. Two thirds of the family contacts of these children showed hepatitis B marker. Two pregnancies were observed in HBsAg-positive mothers. An infection of the babies was not demonstrable.
对372名疑似患有肝病的儿童进行了血清乙肝表面抗原（HBsAg）检测。发现6名儿童呈阳性（3名男孩，3名女孩），占1.6%。对这些患者长达三年半的进一步研究显示，只有1例患者的HBsAg消失。对5名患者进行了活检。3例显示为轻度慢性肝炎（2例为慢性持续性肝炎，1例为非特异性反应性肝炎）。1例患者被诊断为慢性活动性肝炎。1名儿童在光学显微镜下看似正常，但电子显微镜检查结果异常，肝细胞核充满核心颗粒。这些儿童中有三分之二的家庭接触者显示有乙肝标志物。观察到2名HBsAg阳性母亲怀孕。未证实其婴儿受到感染。
