Davis J W, Davis R F
Am J Med Sci. 1979 Sep-Oct;278(2):139-43. doi: 10.1097/00000441-197909000-00004.
The purpose of this study was to determine whether cigarette smoking acutely increased circulating platelet aggregates as detected by lowering of the platelet aggregate ratio. Eighteen (11 male and 7 female) volunteers ranging from 16 to 47 years of age rested during a 20-minute control period and smoked two unfiltered tobacco cigarettes during another 20-minute period. Platelet aggregate ratios (mean +/- SD) before and after the control period were 0.86 +/- 13 and 0.82 +/- 0.12 respectively (p greater than 0.05) and before and after smoking were 0.84 +/- 0.14 and 0.66 +/- 0.18 respectively (p less than 0.01). The mean plasma nonesterified fatty acid concentration was not significantly different before and after smoking suggesting that the decrease in platelet aggregate ratio was not mediated through elevation of the plasma nonesterified fatty acid concentration. Our results are consistent with the theory that platelet aggregates contribute to the increased incidence of myocardial infarction and sudden death from coronary artery disease observed among cigarette smokers.
本研究的目的是通过检测血小板聚集率的降低来确定吸烟是否会急性增加循环血小板聚集体。18名志愿者（11名男性和7名女性），年龄在16至47岁之间，在20分钟的对照期内休息，并在另一个20分钟的时间段内吸两支未过滤的香烟。对照期前后的血小板聚集率（平均值±标准差）分别为0.86±0.13和0.82±0.12（p>0.05），吸烟前后分别为0.84±0.14和0.66±0.18（p<0.01）。吸烟前后血浆非酯化脂肪酸浓度无显著差异，这表明血小板聚集率的降低不是通过血浆非酯化脂肪酸浓度的升高介导的。我们的结果与血小板聚集体导致吸烟者中心肌梗死和冠状动脉疾病猝死发生率增加这一理论相一致。
