Vrabec D P
Ann Otol Rhinol Laryngol. 1979 Nov-Dec;88(Pt 1):846-54. doi: 10.1177/000348947908800620.
Multiple primary carcinomas were found in 11.5% of 1,518 patients presenting with an index tumor in the oral, pharyngeal or laryngeal areas. These additional malignancies were subdivided into two groups: 1) those occurring in distant or unrelated tissues and 2) those occurring in a multicentric zone defined as including the oral area, pharyngeal area, larynx, esophagus and tracheobronchial tree. Although some trends were noted, a primary lesion may be found anywhere in the zone of multicentricity. The dynamic nature of the progressive transition of the potentially malignant tissues in the multicentric zone is reemphasized. The physician, treating patients with head and neck cancer, should be prepared not only to cope with simultaneously occurring primary cancers but also to be constantly vigilant for the later development of subsequent primary carcinomas.
在1518例以口腔、咽或喉部位的索引肿瘤就诊的患者中，11.5%发现了多原发性癌。这些额外的恶性肿瘤被分为两组：1）发生在远处或不相关组织中的；2）发生在一个多中心区域内的，该区域定义为包括口腔区域、咽区域、喉、食管和气管支气管树。尽管注意到了一些趋势，但原发性病变可能出现在多中心区域的任何部位。再次强调了多中心区域内潜在恶性组织进行性转变的动态性质。治疗头颈癌患者的医生不仅应准备好应对同时发生的原发性癌症，还应时刻警惕后续原发性癌的后期发生。
